Undergraduate Courses

Pharmacology and Toxicology Courses

For Distribution Requirement purposes, all PCL courses are classified as SCIENCE courses (BR=4).

For student course evaluations, please visit the PTSA website

*Please note: Following the course title, L = Lecture hours, T = Tutorial hours, P = Practical Lab hours
 

course description, Pre-requisites/Co-requisites coordinator

PCL102H1 

The Art of Drug Discovery (24L)

This course introduces students to the processes and strategies for discovering new drugs with a special focus on current and emerging approaches for the rational design of drugs that are both effective and safe.

Dr. Rebecca Laposa

PCL200H1

Drugs & The Brain [24L]

Lectures introduce students to prescribed and illicit drugs that affect the brain. Lectures cover drug pharmacology and explain how drugs alter mood, perception, cognition, and arousal by affecting different aspects of brain function. The societal impact of these prescribed and illicit drugs is also discussed

  • Prerequisite: None
  • Exclusion: PSY396H1, PCL302H1
  • Distribution Requirement Status: Science Breadth
  • Requirement: Living Things and Their Environment (4)
Dr. Amy Ramsey

PCL201H1

Introduction to Pharmacology: Pharmacokinetic Principles (36L, 6T)

A general introduction to Pharmacology. Topics include absorption, distribution, biotransformation, elimination, calculation of dosages, variability in drug response, adverse drug reactions and special interest topics.

  • Recommended co-requisites: BIO230H (BIO240H1, BIO241H1), CHM247H1/CHM249H1, PSL300H1 and 301H1 (PSL302Y1)
Dr. Michelle Arnot

PCL297H1

Research Experience in Pharmacology and Toxicology (60P)

A formal opportunity to gain hands-on experience and develop skills within a research laboratory setting. Students will have a chance to become familiar and efficient at good lab practices, develop critical thinking and evaluation skills while applying their knowledge and developing trouble shooting skills to practical research questions. This course is Pass/Fail.

  • Prerequisite: None; Permission of Faculty Supervisor and Course Coordinator or Departmental Undergraduate Coordinator required.
  • Recommended Preparation: Completion of at least first year of Life Sciences program.
Dr. Anita Hamadanizadeh

PCL299Y1

Research Opportunity Program

Credit course for supervised participation in faculty research project. See Arts and Science Course Calendar for details or click here for more information: Faculty of Arts and Science Research Opportunity Program.

Dr. Michelle Arnot

PCL302H1

Introduction to Pharmacology: Pharmacodynamic Principles (36L)

Topics include biological action of drugs on membranes, enzymes, receptors, neural and hormonal systems, transmission and modulation.

  • Prerequisites: BIO230H1 (BIO240H1, BIO241H1) CHM 247H1/CHM249H1, PSL300H1 and 301H1 (PSL302Y1)
Dr. Jane Mitchell

PCL345H1

Experimental Approaches in Drug Discovery (24L)

Lecturers use their own research to demonstrate how they approach a biological question. The lectures emphasize why one approach is chosen over other possible approaches, and explain the strengths and limitations of techniques. Following the one-hour lecture there is an interactive discussion of the experimental approach covered in the lecture.

  • Prerequisites: BCH210H1; completion of at least 10 FCE.
  • Recommended Preparation: PSL300H1/PSL301H1 or BIO270H1/BIO271H.
  • Enrolment Limits: Students with 3rd and 4th year standing.
  • Distribution Requirement Status: This is a Science course.
  • Breadth Requirement: Living Things and Their Environment (4).
Dr. Ana Andreaza

PCL362H1

Introductory Toxicology (26L)

Toxicological problems encountered in animals and humans; biochemical mechanisms and clinical factors of toxicological significance; models of drug-related diseases.

  • Prerequisites: BCH210H1, BIO230H (BIO240H1, BIO241H1), CHM247H1/CHM249H1, PCL201H1, PCL302H1 or permission of the Course Coordinator.
  • Recommended Co-requisite: BCH311H1/CSB349H1.

Dr. Peter G. Wells

PCL366H1

Basic Pharmacology & Toxicology Laboratory (32P, 16T)

Through practical hands-on laboratory experiments and tutorials, students will be introduced to some basic experimental techniques that are used within pharmacology and toxicology research.  This course results from the splitting of PCL365Y and PCL471Y and provides students an opportunity to develop introductory and basic laboratory skills. 

  • Prerequisites: PCL201H1, PSL300H1/PSL301H1
  • Co-requisite: PCL302H1
  • Exclusion: PCL365Y/PCL471Y
Dr. Anita Hamadanizadeh

PCL376H1

Experimental Design Data Analysis for Pharmacology and Toxicology (36L)

A practically oriented course, focussed on experimental design and the analysis of pharmacological and toxicological data. Topics include: principles of experimental design, data analysis and statistical tests appropriate for each type, use of computing statistical packages, analysis of dose-response and time-response curves and analysis of receptor binding assays. PCL376H1 can be taken either as a pre-requisite or a co-requisite to the research project course PCL472Y1/PCL474Y1.

  • Prerequisite: PCL201H1 
  • Co-requisite: PCL302H1 
  • Exclusion: PCL476H1
Dr. Laurel Duquette

PCL389H1

Understanding the Role of Pharmacology and Toxicology in Society (24L)

This service learning course explores issues surrounding the effects that pharmaceuticals and chemicals have in society.  In particular it will examine the following as it deals with drug addiction and misuse: scientific background and theory on selected pharmaceuticals and chemicals; complex topics associated with social, legal and governmental policy found in the Pharmacology and Toxicology field with an integration of community-based activities (20 hours).

  • Prerequisite: PCL201H1
  • Co-requisite: PCL302H1; PSL300H1 and 302H1 (PSL302Y1)
Dr. Michelle Arnot

PCL397Y0

Research Abroad in Pharmacology and Toxicology (200P)

An independent research project in a pharmacology and/or toxicology laboratory in an approved partner university. This international research experience will be supervised by a faculty member at the partner institution and will allow students to develop critical thinking and evaluation skills while applying their knowledge and trouble shooting skills to practical research questions

  • Prerequisites: PCL201H1, PCL302H1, PSL300H1, PSL301H1 with a minimum grade of 65%; permission from the Undergraduate Coordinator
  • Enrolment Limits: Pharmacology Specialist, Biomedical Toxicology Specialist, Pharmacology Major, Toxicology Major, Pharmacology and Toxicology Specialist, Environment and Toxicology Specialist, other students in Life Sciences with the appropriate pre-requisite courses.
Dr. Yuliya Lytvyn

PCL402H1

Pharmacology and Toxicology in Drug Development (24L)

The basic principle of drug development with a focus on the application of fundamental principles of pharmacology and toxicology to design and conduct early phase clinical trials. This is the phase of the drug development process where much of the innovation and science occurs.

  • Pre-requisite: PCL201H1, PCL302H1, PSL300H1, PSL301H1
Dr. Rebecca Laposa

PCL461H1

Advanced Pharmacology Laboratory (36P, 12T)

Advanced laboratory exercises and discussions through tutorials and presentations in selected areas of pharmacology. Enrolment in this course is generally restricted to students enrolled in the Pharmacology Specialist and Pharmacology and Biomedical Toxicology Specialist programs.

  • Prerequisites: PCL201H1, PCL302H1, PSL300H1/PSL301H1, PCL366H1.
  • Exclusion: PCL365Y/PCL471Y
  • Recommended Preparation: PCL469H1
Dr. Anita Hamadanizadeh

PCL465H1

Advanced Toxicology Laboratory (32P, 16T)

An advanced hands-on laboratory course exploring a wide variety of modern experimental techniques currently utilized in toxicology.  This course will provide the experimental theory of how the techniques work and their advantages and disadvantages, while additionally allowing sutdents to perform these techniques in the process of addressing toxicological problems.  Enrolment in this course is generally restricted to students enrolled in the Biomedical Toxicology Specialist, Pharmacology and Biomedical Toxicology Specialist, and Environment and Toxicology Specialist programs.

  • Prerequisite: PCL201H1, (PSL300H1, PSL301H1)/PSL302Y1, PCL302H1, PCL362H1, PCL366H1
  • Exclusion: PCL365Y/PCL471Y1
Dr. Anita Hamadanizadeh

PCL469H1
(formerly PCL470Y)

Systems Pharmacology (31L, 4T)

A culmination of pharmacological principles discussing concepts of drug properties and their interactions within the body. The mechanism of action, pharmacological properties including clinical use and adverse effects of drugs acting on the autonomic nervous systems, cardiovascular, renal, respiratory, gastrointestinal and endocrine systems will be examined.  Critical evaluation of primary literature and examination of clinical problem-based case studies will be integrated with lecture material through small group sessions. 

  • Prerequisite: PCL201H1, PCL302H1, (PSL300H1, PSL301H1)/ PSL302Y1, BCH210H1
  • Exclusion: PCL470Y1
Dr. Michelle Arnot

PCL470H1
(formerly PCL470Y1)

Systems Pharmacology II (31L/4T)

A culmination of pharmacological principles discussing concepts of drug properties and their interactions within the body. The mechanism of action, pharmacological properties including clinical use and adverse immunological system; antimicrobial and cancer chemotherapeutic agents; as well as the potential therapeutic use of endogenous/herbal compounds will be examined. Critical evaluation of primary literature and examination of clinical problem-based case studies will be integrated with lecture material through small group sessions. 

  • Prerequisites: PCL201H1, PCL302H1, (PSL300H1, PSL301H1)/(PSL302H1), BCH210H1
Dr. Ali Salahpour

PCL472Y1

Project in Pharmacology (~200P)

This course affords students an opportunity for hands-on research experience in a laboratory or applied pharmacology setting. Students will work under the supervision of a staff member and will submit a final written report. Enrollment is limited and requires permission from the Department of Pharmacology. It is the student's responsibility to secure a placement with an approved supervisor before the course begins (a list of potential supervisors can be obtained from the Department of Pharmacology and Toxicology). Students will be registered in the course once their ballot form (obtained from the Department) is signed by an approved supervisor and approved by the Department of Pharmacology and Toxicology.

  • Prerequisites: PCL201H1, PCL302H1, PCL376H1 (see NOTES above) and permission of Department
  • Co-requisite: PCL376H1 (see NOTES above)
  • Exclusion: PCL474Y1
Dr. Rebecca Laposa

PCL473Y1

Interdisciplinary Toxicology (48L)

A survey course examining traditional and contemporary problems in toxicology. The toxicities associated with a variety of toxins and toxicants are examined. General principles and the application of toxicological knowledge are discussed including clinical toxicology, forensic toxicology, and risk assessment.

  • Prerequisites: BCH210H1, PCL201H1, PCL302H1, PCL362H1 or permission of Course Coordinator 
  • Recommended Preparation:  BCH311H1/CSB349H1

Dr. Peter McPherson

PCL474Y1

Project in Toxicology (~200P)

This course affords students an opportunity for hands-on research experience in a laboratory or applied toxicology setting. Students will work under the supervision of a staff member and will submit a final written report. Enrollment is limited and requires permission from the Department of Pharmacology. It is the student's responsibility to secure a placement with an approved supervisor before the course begins (a list of potential supervisors can be obtained from the Department of Pharmacology and Toxicology). Students will be registered in the course once their ballot form (obtained from the Department) is signed by an approved supervisor and approved by the Department of Pharmacology and Toxicology.

  • Prerequisites: PCL201H1, PCL302H1, PCL376H1 (see NOTES above) and permission of Department
  • Co-requisite: PCL376H1 (see NOTES above)
  • Exclusion: PCL472Y1
Dr. Rebecca Laposa

PCL475Y1

Neuropsychopharmacology (72L, 24T)

Major neuro-psychiatric disease syndromes: clinical pathology and neuronal abnormalities; CNS drugs: theories and mechanisms of action.

  • Prerequisite: Enrollment is limited to students with a minimum CGPA of 3.0. 

Dr. MacIntyre Burnham

PCL477H1

The DNA Damage Response in Pharmacology and Toxicology (24L)

Many anticancer drugs and environmental agents exert their cytotoxic effects through DNA damage. This course explores specific pharmacological and toxicological agents that damage DNA and discusses how mammalian cells respond to this DNA damage. Topics covered include forms of damage caused by pharmacological and environmental agents, DNA repair, DNA damage checkpoints, apoptosis, genomic integrity, cancer, mechanism of cellular resistance to antineoplastics that cause DNA damage.

Marking Scheme: One mid-term exam (25%) and one final exam (50%) are in short-answer/essay format. One writing assignment is in the form of a scientific critique (25%).

  • Prerequisites: BCH210H1/BCH242Y1
  • Recommended Preparation: PCL201H1, PCL302H1, BCH311H1/CSB349H1/JLM349H1/MGY311Y1/PSL350H1
Dr. Peter McPherson

PCL481H1

The Molecular and Biochemical Basis of Toxicology (24L)

The biochemical principles and molecular mechanisms underlying the toxicity of drugs and foreign agents. The sequence of events at the molecular level leading to impairment of cell function and the factors which determine and affect toxicity.

  • Prerequisites: PCL302H1, PCL362H1, BCH210H1
Dr. Denis Grant

PCL484H1

Seminars in Pharmacokinetics and Toxicokinetics (24S)
(Not offered)

Each week a scientist affiliated with the Department of Pharmacology and Toxicology will discuss the application of pharmcokinetic and/or toxicokinetic principles to their research. This area of study plays an important role in clinical medicine and drug development.

  • Prerequisites: PCL201H.
  • Recommended Preparation: PCL302H1.
  • Distribution Requirement Status: This is a Science course. 
  • Breadth Requirement: Living things and Their Environment (4).
 

PCL486H1

Pharmacology of Cancer Signaling (24L)

This course will expand on both classical and cutting edge pharmacological strategies proposed to mitigate the consequences of altered signal transduction in cancer. Students will have the opportunity to develop knowledge on these molecular events and how they can be targeted to improve clinical outcomes. Students will integrate lecture materials with assigned readings and assignments.

  • Prerequisites: PCL201H1, PCL302H1, at least 15 FEC and completion of upper level laboratory course.
  • Recommended Preparation: PCL469H1, PCL470H1 or PCL473Y1. Completion of an upper level laboratory course (PCL366H1, PSL372H1, BCH370H1).
  • Distribution Requirement Status: This is a Science course.
  • Breadth Requirement: Living things and Their Environment (4).
Dr. Leonardo Salmena

PCL491H1

Clinical Pharmacology Principles and Practice (24P, 8L)
 

This course will examine the practical and experimental aspects of clinical pharmacology and toxicology. Through practical applications and experiments, students will develop their knowledge in  Good Laboratory Practice/Good Clinical Practice, critical evaluation and analysis skills through: performing pharmacokinetic experiments (evaluating Vd, half-life, and clearance); examining case studies and primary literature in regards to drug-drug interactions and adverse drug reactions.

This elective course can be applied towards program requirements in our Specialist and Major streams, and will be available only to fourth-year students.  The course will meet a need for expanding students' comprehension in clinical pharmacology and pharmacokinetics in a hands-on, practical and advanced manner.  Students will be evaluated on both written and oral communication skills; team work as well as data analysis and interpretation; and critical thinking skills.

  • Prerequisites: PCL201H1, PCL302H1, at least 15 FCEs and completion of upper level laboratory course.
  • Recommended Preparation: PCL469H1, PCL470H1 or PCL473Y1. Completion of an uppre level laboratory course (PCL366H1, PSL372H1, BCH370H1)
Dr. Anita Hamadanizadeh

 

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