Albert H.C. Wong, M.D., Ph.D., F.R.C.P.(C)
Professor of Psychiatry, Pharmacology, Institute of Medical Sciences
Our lab is interested in disease mechanisms in psychiatric illnesses like schizophrenia and depression. We use animal models to investigate gene x environment interactions, epigenetics, transcription and neurodevelopment. We also have human clinical samples and studies probing spatial navigation in a VR environment.
Students have the opportunity to work on a number of related projects:
(1) Disc1 gene mutant mouse models - characterization of genetic and environmental effects on neuron migration during cortical development;
(2) Novel brain RNA transcripts regulating sensory gating in rodents as an endophenotype for schizophrenia;
(3) Heritability of DNA methylation profiles and effects on behavioural phenotype in the mouse;
(4) Spatial navigation in schizophrenia as a probe for hippocampal function using VR.
Selected Publications:Zhai D, Lee FHF, D’Souza C, Su P. Zhang S, Jia J, Zhang L, Wong AHC, Liu F. Blocking the GluR2-GAPDH Interaction Ameliorates Experimental Autoimmune Encephalomyelitis. Annals of Clinical and Translational Neurology 2015 Apr;2(4):388-400. doi: 10.1002/acn3.182.
Su P, Li S, Chen S, Lipina TV, Wang M, Lai TKY, Lee FHF, Zhang H, Zhai D, Ferguson SG, Nobrega JN, Wong AHC, Roder JC, Fletcher PJ, Liu F. A Dopamine D2 Receptor-DISC1 Protein Complex May Contribute to Antipsychotic-like Effects. Neuron 2014 Dec 17;84(6):1302-16. doi: 10.1016/j.neuron.2014.11.007.Zawadzki JA, Girard TA, Foussias G, Rodrigues A, Siddiqui I, Lerch JP, Grady C, Remington G, Wong AH: Simulating real world functioning in schizophrenia using a naturalistic city environment and single-trial, goal-directed navigation. Frontiers in Behavioral Neuroscience. 2013; 7:180. doi: 10.3389/fnbeh.2013.00180.
Lipina TV, Zai C, Hlousek D, Roder JC, Wong AHC: Maternal immune activation during gestation interacts with Disc1 point mutation to exacerbate schizophrenia-related behaviours in mice. The Journal of Neuroscience; May 1, 2013: 33(18):7654 –7666.
Lipina TV, Haque FN, McGirr A, Boutros PC, Berger T, Mak TW, Roder JC, Wong AH. Prophylactic Valproic Acid Treatment Prevents Schizophrenia-Related Behaviour in Disc1-L100P Mutant Mice. PLoS One. 2012; 7(12):e51562.
Haque FN, Lipina TV, Roder JC, Wong AH. Social defeat interacts with Disc1 mutations in the mouse to affect behaviour. Beh Brain Res. 2012; 233(2): 337–344.Lee FH, Kaidanovich-Beilin O, Roder JC, Woodgett JR, Wong AH: Genetic inactivation of GSK3α rescues spine deficits in Disc1-L100P mutant mice, Schizophrenia Res. 2011 Jun; 129 (1) 74-79.
Lee FH, Preston-Maher K, Fadel MP, Cordes SP, Clapcote SJ, Price DJ, Roder JC, Wong AHC: Disc1 point mutations in mice alter development of the cerebral cortex. J Neurosci. 2 March 2011, 31(9):3197-3206.
Souza RP, Romano-Silva M, Lieberman JA, Meltzer HY, MacNeil LT, Culotti JG, Kennedy JL, Wong AHC: Genetic association of the GDNF alpha receptor genes with schizophrenia and clozapine response. J Psychiat Res. 2010 Aug; 44(11):700-6.
Rastogi A, Zai C, Likhodi O, Kennedy JL, Wong AHC: Genetic association and post-mortem brain mRNA analysis of the DISC1 gene in schizophrenia. Schizophrenia Res. 2009 Vol. 114, Issue 1, Pages 39-49.
Labrie V, Fukumura R, Rastogi A, Fick LJ, Wang W, Boutros PC, Kennedy JL, Semeralul MO, Lee FH, Baker GB, Belsham DD, Barger SW, Gondo Y, Wong AH, Roder JC: Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model. Hum Mol Genet. 2009 Sep 1;18(17):3227-43.
Kaminsky ZA, Tang T, Wang SC, Ptak C, Oh G, Wong AHC, Feldcamp LA, Virtanen C, Halfvarsson J, Tysk C, McRae A, Visscher P, Montgomery GW, Gottesman II, Martin NG, and Petronis A: DNA methylome studies in twins. Nature Genetics. 2009; 41, 240 – 245.
Semeralul MO, Boutros PC, Likhodi O, Okey AB, Van Tol HHM, Wong AHC: Microarray analysis of the developing cortex. J Neurobiology. 2006 Dec; 66(14):1646-58.
Wong AHC, Gottesman I, Petronis A: Phenotypic differences in genetically identical organisms: the epigenetic perspective. Human Mol Gen. 2005; 14(R1): R11-18.
Wong AHC, Trakalo J, Likhodi O, Yusuf M, Macedo A, Azevedo M-H, Klempan T, Pato MT, Honer WG, Pato CN, Van Tol HHM, Kennedy JL: Association between schizophrenia and the syntaxin 1a gene. Biol Psychiat. 2004; 56(1):24-29.
Wong AHC, Macciardi F, Klempan T, Kawczynski W, Barr CL, Lakatoo S, Wong M, Buckle C, Trakalo J, Boffa E, Oak J, Azevado M-H, Dourado A, Coelho I, Macedo A, Vicente A, Valente J, Paz Ferreira C, Pato MT, Pato CN, Kennedy JL, Van Tol HHM: The identification of candidate genes for psychosis in rat models and possible association between schizophrenia and the 14-3-3 gene. Mol Psychiat. 2003; 8(2):156-166.
Wong AHC, Voruganti LNP, Hesselgrave RJ, Awad AG: Neurocognitive Deficits and Neurological Signs in Schizophrenia. Schizophrenia Res. 1997; 23(2):139-146.
Centre for Addiction & Mental Health
250 College Street
Phone: 416-535-8501, Ext 34010