Faculty: Johan N.M. Heersche, PhD

Johan N.M. Heersche, PhDJohan N.M. Heersche, PhD
Professor Emeritus

General Research Area: Molecular Pharmacology/Endocrinology
Regulation of Cellular Activity and Differentiation of Bone Cells


Selected Publications:

Shoji K, Basso N, Elsubeihi ES, Heersche JN. Short-term effect of ovariectomy on osteoprogenitors in the healing rat mandibular incisor extraction socket. Osteoporos Int.2008 Feb 5; [Epub ahead of print] 

Elsubeihi ES, Bellows CG, Jia Y, Heersche JN. Ovariectomy of 12-month-old rats: effects on osteoprogenitor numbers in bone cell populations isolated from femur and on histomorphometric parameters of bone turnover in corresponding tibia. Cell Tissue Res. 2007 Dec;330(3):515-26. Epub 2007 Oct 16. 

Gramoun A, Shorey S, Bashutski JD, Dixon SJ, Sims SM, Heersche JN, Manolson MF. Effects of Vitaxin, a novel therapeutic in trial for metastatic bone tumors, on osteoclast functions in vitro. J Cell Biochem. 2007 Oct 1;102(2):341-52. 

Trebec DP, Chandra D, Gramoun A, Li K, Heersche JN, Manolson MF. Increased expression of activating factors in large osteoclasts could explain their excessive activity in osteolytic diseases. J Cell Biochem. 2007 May 1;101(1):205-20. 

Pei W, Bellows CG, Jia Y, Heersche JN. Effect of age on progesterone receptor expression, and osteoprogenitor proliferation and differentiation in female rat vertebral cell populations. J Endocrinol. 2006 Aug;190(2):261-70. 

Bellows CG, Jia D, Jia Y, Hassanloo A, Heersche JN. Different effects of insulin and insulin-like growth factors I and II on osteoprogenitors and adipocyte progenitors in fetal rat bone cell populations. Calcif Tissue Int. 2006 Jul;79(1):57-65. Epub 2006 Jul 31. 

Ochotny N, Van Vliet A, Chan N, Yao Y, Morel M, Kartner N, von Schroeder HP, Heersche JN, Manolson MF. Effects of human a3 and a4 mutations that result in osteopetrosis and distal renal tubular acidosis on yeast V-ATPase expression and activity. J Biol Chem. 2006 Sep 8;281(36):26102-11. Epub 2006 Jul 13. 

Basso N, Heersche JN. Effects of hind limb unloading and reloading on nitric oxide synthase expression and apoptosis of osteocytes and chondrocytes. Bone. 2006 Oct;39(4):807-14. Epub 2006 Jun 12.

Basso N, Jia Y, Bellows CG, Heersche JN. The effect of reloading on bone volume, osteoblast number, and osteoprogenitor characteristics: studies in hind limb unloaded rats.Bone. 2005 Sep;37(3):370-8.


Faculty of Dentistry 
124 Edward Street 
Toronto, Ontario 
M5G 1G6 
Phone: [416]978-4921 X4444 
FAX: [416]978-4936 
E-mail: johan.heersche@utoronto.ca