Faculty: Jane Mitchell, PhD

Professor & Associate Chair
Department of Pharmacology and Toxicology

General Research Area: Signal Transduction/ Receptor Pharmacology
Regulation of G protein-Coupled Receptor Signaling Systems in Bone and Retina

Research in my laboratory focuses on several topics. CIHR-funded projects In the skeletal system  investigate the effects of glucocorticoids on bone and muscle. We utilize mouse models to determine the molecular mechanisms through which glucocorticoids inhibit bone growth and cause osteoporosis.  We also examine the effect of glucocorticoids on the skeletal system in mouse models of Duchenne muscular dystrophy.

Our NSERC-funded research projects investigate visual signalling systems using purified proteins to investigate the structural interactions between rhodopsin, G protein subunits, arrestin, receptor kinase and phospholipase C.

PubMed

Selected Publications: 

  1. Dela Cruz A. Grynpas MD, Mitchell J. (2016). Overexpression of Gα11 in osteoblast lineage cells suppresses the osteoanabolic response to intermittent PTH and exercise.  Calcif Tiss Int. 4:423-34
  2. Yoon S-H, Chen JJ, Grynpas MD, Mitchell J. (2016) Prophylactic pamidronate partially protects from glucocorticoid-induced bone loss in the mdx mouse model of Duchenne  muscular dystrophy. Bone 90:168-80.
  3. Dela Cruz A. Grynpas MD, Mitchell J. (2016) Elevated Gα11 expression in osteoblast lineage cells promotes osteoclastogenesis and leads to enhanced trabecular bone accrual  in response to pamidronate. Am J PhysiolEndocrinolMetab. 310:E811-20
  4. Yoon S-H, Sugamori KS, Grynpas MD, Mitchell J. (2016) Positive effects of bisphosphonates on bone and muscle in a mouse model of Duchenne muscular dystrophy. NeuromusculDisord. 26:73-84
  5. Robinson KA, Ou WL, Guan X, Sugamori KS, Bandyopadhyay A, Ernst OP, Mitchell J. (2015)  The effect of phosphorylation on arrestin-rhodopsin interaction in the squid visual system.J Neurochem. 135:1129-1139
  6. Dela Cruz A, Mattocks M, Sugamori KS, Grynpas MD, Mitchell J.(2014) Reduced trabecular bone mass and strength in mice overexpressing Gα11 protein in cells of the osteoblast lineage. Bone 59: 211-222.
  7. Mitchell J (2013) Regulation of hepatic glucose production by Gq-coupled receptors: potential new targets for treatment of type 2 diabetes. Endocrinology 54(10):3495-7.
  8. Barbuto R, Mitchell J. (2013) Regulation of the osterix (Osx, Sp7) promoter by osterix and its inhibition by parathyroid hormone. J MolEndocrionol51(1):99-108.
  9. Mitchell J, Lai LP, Peralta F, Xu Y, Sugamori K. (2011) β2-Adrenergic Receptors Inhibit the Expression of Collagen Type II in Growth Plate Chondrocytes by Stimulating the AP-1 Factor Jun-B. Am J PhysiolEndocrinolMetab. 300:E633-E639
  10. Hong SHH, Lu X, Names SM, Mitchell J. (2009) Regulation of osterix (Osx, Sp7) and the Osx promoter by parathyroid hormone in osteoblasts. J Mol Endo 43:197-207.
  11. Tong D, Rozas N, Oakley T, Mitchell J, Colley N, McFall-Ngai M. (2009)Evidence for light perception in a bioluminescent organ. Proc Natl AcadSci USA.106:9836-41.   Paper was featured on NPR and CBC radio Quirks and Quarks (http://www.cbc.ca/quirks/media/2008-2009/mp3/qq-2009-06-06_02.mp3)
  12. Lai LP, Mitchell J (2009) Parathyroid hormone inhibits phosphorylation of mitogen- activated protein kinase (MAPK) ERK1/2 through inhibition of c-Raf and activation of   MKP-1 in osteoblastic cells. Cell BiochemFunct. 27(5):269-75

 

Contact:

Department of Pharmacology and Toxicology 
Medical Sciences Building, Room 4342
1 King's College Circle 
Toronto, Ontario 
M5S 1A8
Phone: [416]978-0841 
Email: jane.mitchell@utoronto.ca