Faculty: Irena Nulman, MD, PhD, FRCP(C)

Irena Nulman, MD, PhD, FRCP(C)Irena Nulman, MD, PhD, FRCP(C)
Professor of Pediatrics, University of Toronto
Associate Director Motherisk Program
Senior Associate Scientist, Research Institute, Hospital for Sick Children

General Research Areas:  Clinical Pharmacology, Neuropharmacology/Psychopharmacology, and Reproductive Toxicology, Behavioral Teratology (Child Neurodevelopment)

Dr. Nulman is a Professor of Pediatrics , Program Director of Fellowship Training in Clinical Pharmacology  at the University of Toronto, Staff Pharmacologist and Associate Director of the Motherisk Program at the Division of Clinical Pharmacology and Toxicology at the Hospital for Sick Children.

She received her medical degree from Ternopol Medical School in Ukraine, where she completed her residency in Internal Diseases. Dr. Nulman received a Certificate in Neurology in Israel, specializing in Neuropharmacology, and served as a Staff Neurologist at Carmel Hospital, Technion Haifa. Subsequently, she completed her training in Pharmacology and Reproductive Toxicology at the Division of Clinical Pharmacology, Hospital for Sick Children, in Toronto, Canada. She joined the faculty in 2004 and received the FRCPC in Neurology in 2008. She is the Director of the Fetal Alcohol Syndrome Clinic at the Hospital for Sick Children.

Dr. Nulman is an Associate Scientist at the Research Institute. She is an expert in behavioural teratology of psychotropic drugs (anticonvulsant, antidepressant, alcohol) as well as the antiemetic, immunosuppressive and antineoplastic medications. In collaboration with psychology division she established the first Behavioural Teratology Program in Canada and participated in the development of the Canadian National Guidelines in diagnosing Fetal Alcohol Spectrum Disorder with innovation in the measurement of facial dysmorphology. Moreover, Dr. Nulman established the National Survey to promote research on cancer in pregnancy in order to ensure safe pregnancies for this vulnerable population. She contributes extensively to behavioral teratology research and methodology and is an author of ground-breaking publications in this field.


Selected Publications:

Gali Pariente MD1, Tom Leibson MD1, Talya Shulman1, Thomasin Adams-Webber2, Eran Barzilay MD PhD3 and Irena Nulman "Pregnancy outcomes following in utero exposure to lamotrigine- A systematic review and meta- analysis."   2017 - CNS Drugs , In revision 

Diav-Citrin O, Shechtman S, Arnon J, Wajnberg R, Borisch C, Beck E, Richardson JL, Bozzo P, Nulman I, Ornoy A. Methylphenidate in pregnancy: A multicenter, prospective, comparative, observational study. J Clin Psychiatry 2016 ;77(9):1176-1181

Terrana N, Koren G, Pivovarov J, Etwel F, Nulman I. Pregnancy outcomes following in-utero exposure to second generation antipsychotics: a systematic review and meta-analysis. J Biol Psychiatry 2015 : 35 (5):559-65

Nulman I, Koren G, Rovet J, Barrera M, Streiner DL, Feldman BM. Neurodevelopment of Children Prenatally Exposed to Selective Reuptake Inhibitor Antidepressants: Toronto Sibling Study.  J Clin Psychiatry 2015;76(7):e842–e847

Kaplan YC, Ozsarfati J, Nickel C, Nulman I, Koren G. Pregnancy Outcome Following First Trimester Exposure to Topical Retinoids: A Systematic Review and Meta-Analysis. The British Journal of Dermetology 2015 Jul Jul;173 (5):1132-1141

Marchenko A, Etwel F, Olukayode O, Nickel C, Koren G, Nulman I. Pregnancy Outcome Following Prenatal Exposure to Triptan Medications: A Meta-Analysis. Headache: The Journal of Head and Face Pain. April, 2015; 55 (4): 490-501

Amant F, Halaska M, Fumagalli M, Dahl Steffensen K, Lok C, Van Calsteren K, Han S, Mir O, Fruscio R, Uzan C, Maxwell C, Dekrem J, Strauven G, Mhallem Gziri M, Kesic V, Berveiller P, Van den Heuvel F, Ottevanger N, Vergote I, Lishner M, Morice P, Nulman I. Gynecologic Cancers in Pregnancy: guidelines of a second international consensus meeting.  SRA , Int J Gynecol Cancer. 2014 Mar;12(3):394-403

Choi JS, Koren G, Nulman I. Pregnancy and isotretinoin therapy. CMAJ, 2013 Mar 19;185(5):411-3

Nulman I. Carbamazepine in pregnancy. Editorial. BMJ 2010 Dec; 341:c6582

Sadowski A, Todorow M, Yazdani Brojeni P, Koren G, Nulman I. Pregnancy outcomes following maternal exposure to second-generation antipsychotics given with other psychotropic drugs: a cohort study. BMJ Open. 2013 Jul 13;3:e00306

Nulman I, Koren G, Rovet J, Barrera M, Pulver A, Streiner D, Feldman B.  Neurodevelopment of Children Following Prenatal Exposure to Venlafaxine, Selective Serotonin Reuptake Inhibitors, or Untreated Maternal Depression. Am J Psychiatry. 2012 Nov 1;169(11):1165-74

Koren G, Nulman I, Aleksa K, Gareri J, Einarson A, Ito S. Essay for the 2011 CIHR/CMAJ Award: Motherisk – caring for mothers, protecting the unborn. CMAJ 2012 Feb


Irena Nulman MD, MSc, FRCPC Neurology, PhD
Professor of Pediatrics, Pharmacology, and Pharmacy, University of Toronto
Staff, Division of Clinical Pharmacology and Toxicology
The Hospital for Sick Children,
University of Toronto Fellowship Program Director, Clinical Pharmacology,
Senior Associate Scientist Child Health Evaluative Sciences (CHES)
Research Institute
Phone: 416-813-7887

E-Mail: irena.nulman@sickkids.ca