Faculty: Cecil Pace-Asciak, PhD

Cecil Pace-Asciak, PhDCecil Pace-Asciak, PhD
Professor Emeritus, Pharmacology
Senior Scientist Emeritus, Physiology and Experimental Medicine Programme, Hospital For Sick Children

General Research Areas: Biochemical Pharmacology; Hepoxilins and Stable Hepoxilin Analogs and isolation of biologically active natural products.

Not taking new graduate students

Selected Publications:

Pace-Asciak, Cecil, R. Hepoxilins in Cancer and Inflammation – use of hepoxilin antagonists. Cancer Metastasis Rev. 2011 Dec;30(3-4):493-506. doi: 10.1007/s10555-011-9307-y. Review.

Cecil R Pace-Asciak, Hepoxilins and Some Analogs - A Review of Their Biology.  Br. J. Pharmacology. 2009; 1 58: 972-981.

Etienne Pouteau, Olivier Apriklan, Catherine Grenot, Denis Reynaud, Cecil Pace-Asciak, et al. A low alpha-linoleic intake during early life increases adiposity in the adult guinea pig. Nutrition & Metabolism; 7: 8-16, 2010. Open access viewing at: www.nutritionandmetabolism.com/content/7/1/8.  

Qiao N, Reynaud D, Abdelhaleem M, Pace-Asciak CR. Hepoxilin analogs, PBT-3 and PBT-4, cause apoptosis of Gleevec-resistant K562 cells in vitro. In Vivo. 2007;21(2):267-71. 

Hanson J, Reynaud D, Qiao N, Devel P, Moray AL, Renard JF, Kelley LP, Winum JY, Montero JL, Kinsella BT, Pirotte B, Pace-Asciak CR, Dogné JM. Synthesis and pharmacological evaluation of novel nitrobenzenic thromboxane modulators as antiplatelet agents acting on both the alpha and beta isoforms of the human thromboxane receptor. J Med Chem. 2006; 49(12):3701-9. 

Copland IB, Reynaud D, Pace-Asciak C, Post M. Mechanotransduction of stretch-induced prostanoid release by fetal lung epithelial cells. Am J Physiol Lung Cell Mol Physiol.2006 Sep; 291(3):L487-95. Epub 2006 Apr 7. 

Pace-Asciak CR, Li X, Qiao N, Reynaud D, Demin P, Abdelhaleem M. Hepoxilin analogs, potential new therapeutics in disease. Curr Pharm Des. 2006; 12(8):963-9. 

Dogné JM, Hanson J, de Leval X, Pratico D, Pace-Asciak CR, Drion P, Pirotte B, Ruan KH. From the design to the clinical application of thromboxane modulators. Curr Pharm Des. 2006; 12(8): 903-23. Review. 

Li X, Qiao N, Reynaud D, Abdelhaleem M, Pace-Asciak CR. PBT-3, a hepoxilin stable analog, causes long term inhibition of growth of K562 solid tumours in vivo. Biochem Biophys Res Commun. 2005 Dec 9; 338(1):158-60. Epub 2005 Aug 10. 

LI X, Qiao N, Reynaud D, Abdelhaleem M and Pace-Asciak CR. The Hepoxilin Analog, PBT-3, inhibits the growth of K-562 CML Solid Tumours in vivo in Nude Mice. In Vivo. 2005; 19:185-190.  

Qiao N, Reynaud D, Demin P, Halushka P and Pace-Asciak, C.R. The thromboxane receptor antagonist PBT-3, a hepoxilin stable analog, selectively antagonizes the TPa isoform in transfected COS-7 cells. JPET. 2003; 307:1142-1147. 

Pace-Asciak CR, Reynaud D, Demin P, Aslam R and Sun A. A new family of thromboxane receptor antagonists with secondary thromboxane synthase inhibition. JPET. 2002;301:618-624. 

Jankov, R.P., Luo, XP., Demin, P., Aslam, R., Hannan, V., Tanswell, A.K. and Pace-Asciak, C.R. Hepoxilin analogs inhibit bleomycin-induced pulmonary fibrosis in the mouse.JPET. 2002; 301:435-440. 

Pace-Asciak, C.R., Demin, P.M., Estrada, M. and Liu, G-L. Hepoxilins raise circulating insulin levels in vivo. FEBS Letters. 1999; 461:165-168.


The Hospital For Sick Children Research Institute

Programme in Translational Medicine

Rm 09.9716, PGCRL
686 Bay Street
Toronto, ON 
M5G 0A4
Phone: 416-813-5755 (office), 416-828-1959 (cell)
Email: cpa0442@gmail.com
Website: Sick Kids