Dr. Kotsopoulos returned to Canada as an independent researcher in 2009 as a recipient of a Cancer Care Ontario Chair in Population Studies. She has been awarded the Canadian Gene Cure Foundation/CIHR Champion of Genetics Grant and the Canadian Cancer Society Career Development Award in Prevention. Her research program is dedicated at furthering our understanding of BRCA-associated breast and ovarian cancer with the intent of identifying strategies that confer substantial risk reduction and improve outcome. Her efforts include identifying inherent markers (host factors) in BRCA-mutation carriers. This research may translate into putative targets for chemoprevention.
Dr. Kotsopoulos directs molecular studies aimed at characterizing BRCA genes as haploinsufficient tumor suppressor genes and investigate whether one can modulate cancer risk by affecting gene or protein expression. The overall goal of her research is to provide women with a wider choice of less-invasive options to reduce their risk of breast and ovarian cancer.
She also leads several projects aimed to improve our understanding of factors that impact ovarian cancer prognosis, a highly fatal disease.
Dr. Kotsopoulos is actively involved in teaching and mentoring of both undergraduate and graduate student at UofT.