John Oldenhof MSc, PhD
Vice President Clinical Pharmacology, BioPharma Services Inc
Adjunct Lecturer
John Oldenhof MSc, PhD
Contact Info
T: (416) 747-8484 x222
Location
BioPharma Services Inc
4000 Weston Road
Toronto, ON, M9L 3A2
Research Interests
Clinical Pharmacology, Drug Development, First in Human, Abuse Potential, Drug-Drug Interactions and Genetic Epilepsy Syndromes

Dr. Oldenhof obtained his Master's in Behavioural Pharmacology, studying reward mechanisms, and his PhD in Molecular Pharmacology, investigating intracellular protein-protein interactions with the dopamine D4 receptor, at the University of Toronto. Dr. Oldenhof has worked in biotech and early stage drug development for over 18 years. His focus has been on Clinical Pharmacology studies, including first-in-human, drug-drug interaction studies and human abuse potential studies. He has a special interest in therapeutic strategies for single gene epilepsy disorders. Dr. Oldenhof is currently Vice President Clinical Pharmacology at BioPharma Services. He oversees a team of clinical research scientist, pharmacokinetic scientists, data managers and statisticians.

Publications and Awards

Recent Publications

  1. Oak JN, Oldenhof J and Van Tol HHM (2000) The Dopamine D(4) Receptor: One Decade of Research. Eur. J. Pharmacol. 405: 303-327.
     
  2. Oldenhof J, Hochberg M, Schiff M and Brune K (2010) The Effect of Maximum Over-the-Counter Doses of Naproxen Sodium or Acetaminophen on Low-Dose Aspirin Inhibition of Serum Thromboxane B2. Curr Med Res Opin. 26:1497-504.
     
  3. Oldenhof J, Ray A and Van Tol HHM (2001) SH3 Ligands in the Dopamine D3 Receptor. Cell. Signal. 13: 411-416.
     
  4. Oldenhof J, Vickery R, Anafi M, Oak J, Ray A, Schoots O, Pawson T, von Zastrow M and Van Tol HHM (1998) SH3 Binding Domains in the Dopamine D4 Receptor. Biochemistry 37: 15726-15736.
     
  5. Schiff M, Hochberg MC, Oldenhof J and Brune K (2009) Platelet Inhibitory Effects of OTC Doses of Naproxen Sodium Compared with Prescription Dose Naproxen Sodium and Low-Dose Aspirin. Curr Med Res Opin. 25:2471-7.
     
  6. Setnik B, Sokolowska M, Johnson F, Oldenhof J and Romach M (2014) Evaluation of the Safety, Pharmacodynamic, and Pharmacokinetic Effects Following Oral Coadministration of Immediate-Release Morphine with Ethanol in Healthy Male Participants. Hum Psychopharmacol. 29:251-65.
     
  7. Torres Filho IP, Spiess BD, Barbee RW, Ward K, Oldenhof J and Pittman R (2004) Systemic Responses to Hemodilution after Transfusion with Stored Blood and with a Hemoglobin-based Oxygen Carrier. Anesth Analg. 100: 912-920.