Cindy Woodland, Ph.D.

Senior Lecturer - Not taking graduate students General Area of Research: Toxicology, Drug Metabolism, Clinical Pharmacology Drug Biotransformation and Transport

My research focus is drug-induced toxicity, particularly that involving drug metabolizing enzymes and/or drug transporters. I am interested in the ontogeny, expression, and function of P-glycoprotein and other drug transporters and their involvement in drug-drug interactions. I also study the mechanisms of bioactivation and detoxification of potentially nephrotoxic species. My clinical research interests include drug-induced renal toxicity and the safety of drugs in pregnancy. 

Please note: My current administrative duties prevent me from doing any active research. Therefore, I am not accepting any graduate or summer students.

Selected Publications:

Woodland C, Huang TT, Gryz E, Fawcett JP, Bendayan R. Expression, Activity and Regulation of CYP3A in Human and Rodent Brain. Drug Metab Rev. 2008; 40(1):149-68.

Chen N, Aleksa K, Woodland C, Rieder M, Koren G. N-Acetylcysteine prevents ifosfamide-induced nephrotoxicity in rats. Br J Pharmacol. 2008 Feb 18; [Epub ahead of print].

Chen N, Aleksa K, Woodland C, Rieder M, Koren G. Prevention of ifosfamide nephrotoxicity by N-acetylcysteine: clinical pharmacokinetic considerations. Can J Clin Pharmacol. 2007; 14(2):e246-50.

Chen N, Aleksa K, Woodland C, Rieder M, Koren G. The effect of N-acetylcysteine on ifosfamide-induced nephrotoxicity: in vitro studies in renal tubular cells. Transl Res. 2007; 150(1):51-7.

Sarkar M, Woodland C, Koren G, Einarson AR. Pregnancy outcome following gestational exposure to azithromycin. BMC Pregnancy Childbirth. 2006; 6:18.

Chen N, Aleksa K, Woodland C, Rieder M, Koren G. Ontogeny of drug elimination by the human kidney. Pediatr Nephrol. 2006; 21(2):160-8.

Pinto N, Halachmi N, Verjee Z, Woodland C, Klein J, Koren G. Ontogeny of renal P-glycoprotein expression in mice: correlation with digoxin renal clearance. Pediatr Res. 2005; 58(6):1284-9.

Contact Address: University of Toronto
Department of Pharmacology and Toxicology
Room 4209, Medical Sciences Building
1 King's College Circle
Toronto, Ontario
M5S 1A8
Phone: [416]978-3102
FAX: [416]978-6395
Email: cindy.woodland@utoronto.ca