Claudio Naranjo, M.D.

Professor General Area of Research: Clinical Pharmacology/Clinical Psychopharmacology Pharmacotherapy of Alcoholism and Drug Dependence/Toxicity of Psychoactive Drugs/Geriatric Psychopharmacology/Pharmacotherapy of Mood Disorders

Our research can be grouped into the following: 1) Pharmacotherapy of drug dependence. Projects are aimed at identifying and evaluating efficacy and mechanisms of pharmacotherapies for alcoholism and drug dependence; 2) Toxicity and treatment outcome of psychoactive drugs: Projects assess: a) clinical relevance and mechanisms of psychoactive drug interactions (with an emphasis on isozyme specific interactions), b) fuzzy logic theory and applications to pharmacology [e.g., new modelling pharmacokinetics/ pharmaco-dynamics techniques; assessment of treatment outcome (e.g. efficacy, adverse drug reactions)] c) methods for assessing adverse drug reactions; 3) Geriatric Psychopharmacology: evaluations of mechanisms and pharmacotherapy of dementia and behavioural disorders associated with dementia; 4) Pharmacotherapy of Mood Disorders: Projects assess: a) neurobiological mechanisms of depression; b) predicting patterns of response to antidepressants and mood stabilizers.

Selected Publications:

Naranjo CA, Dongier M, Bremner KE. Long-acting injectable bromocriptine does not reduce relapse in alcoholics. Addiction 92: 969-978 (1997).

Naranjo CA, Bremner KE, Bazoon M, Turksen IB. Using fuzzy logic to predict response to citalopram in alcohol dependence. Clinical Pharmacology and Therapeutics 62: 209-224 (1997).

Sproule BA, Bazoon M, Shulman KI, Turksen IB, Naranjo CA. Fuzzy logic pharmacokinetic modelling: Application to lithium concentration prediction. Clinical Pharmacology &Therapeutics 62: 29-40 (1997).

Ozdemir V, Naranjo CA, Herrmann N, Reed K, Sellers EM, Kalow W. Paroxetine potentiates CNS side effects of perphenazine: Contribution of cytochrome P450 2D6 inhibition in vivo. Clinical Pharmacology and Therapeutics 62: 334-347 (1997).

Naranjo CA, Herrmann N, Mittmann N, Bremner KE. Recent advances in geriatric psychopharmacology. Drugs and Aging 7: 184-202 (1995).

Contact Address: Sunnybrook & Women's College Health Sciences Center
Psychopharmacology Research Group
Room FG03
2075 Bayview Avenue
Toronto, Ontario
M4N 3M5
Phone: [416]480-6761
FAX: [416]480-4708
Email: claudio.naranjo@utoronto.ca