Pharmacology and Toxicology

Christian Hendershot Ph.D.
Senior Scientist
Associate Professor
Christian Hendershot
Contact Info
T: (416) 535-8501 36730
Location
Centre for Addiction and Mental Health
100 Stokes St., 3169
Toronto, ON, M6J 1H4
Appointments
Department of Psychiatry
Department of Psychological Clinical Science
Department of Phamacology & Toxicology
Research Interests
etiology, treatment and behavioural pharmacology of addictive behaviours

Dr. Hendershot is a Senior Scientist at the Centre for Addiction and Mental Health and Associate Professor in the Departments of Psychiatry, Psychology, and Pharmacology & Toxicology at the University of Toronto. Dr. Hendershot’s research focuses on the etiology, treatment and behavioural pharmacology of addictive behaviours. Specific areas of interest include cognitive, genetic and psychopharmacological risk factors for the development of substance use disorders, and behavioural pharmacology of alcohol and other drugs, and the application of human laboratory models to study addiction liability and treatment efficacy. Dr. Hendershot supervises graduate students through the Graduate Department of Psychology, the Graduate Department of Psychological Clinical Science, and the Department of Pharmacology & Toxicology at the University of Toronto.

Publications and Awards

View PubMed search of this faculty member's recent publications.

Recent Publications

Nona, C.N., Hendershot, C.S., & Le Foll, B. (2019). Effects of cannabidiol on alcohol-related outcomes: A review of preclinical and human research. Experimental and Clinical Psychopharmacology (Epub ahead of print).

Lindgren, K.P., Hendershot, C.S., Ramirez, J.J., Bernat, E., Rangel-Gomez, M., Peterson, K.P., & Murphy, J.G. (2019). A dual process perspective on advances in cognitive science and alcohol use disorder. Clinical Psychology Review, 69, 83-96.

Dermody, S.S., Hendershot, C.S., Andrade, A., & Tyndale, R.F. (2018). Changes in nicotine metabolite ratio among daily smokers receiving treatment for alcohol use disorder. Nicotine & Tobacco Research (Epub ahead of print).

Nona, C.N., Hendershot, C.S., & Lê, A.D. (2018). Behavioral sensitization to alcohol: Bridging the gap between preclinical research and human models. Pharmacology, Biochemistry and Behavior, 173, 15-26.

Hendershot, C.S., Wardell, J.D., Vandervoort, J., McPhee, M.D., Keough, M.T., & Quilty, L.C. (2018). Randomized trial of working memory training as an adjunct to inpatient substance use disorder treatment. Psychology of Addictive Behaviors, 32, 861-872.

Wardell, J.D., Le Foll, B., & Hendershot, C.S. (2018). Preliminary evaluation of a human laboratory model of impaired control over alcohol using intravenous alcohol self-administration. Journal of Psychopharmacology, 32, 105-115.

Hendershot, C.S., Wardell, J.D., Samokhvalov, A.V., & Rehm, J. (2017). Effects of naltrexone on alcohol self-administration and craving: Meta-analysis of human laboratory studies. Addiction Biology, 22, 1515-1527.

Hendershot, C.S., Wardell, J.D., McPhee, M.D., & Ramchandani, V.A. (2017). A prospective study of genetic factors, human laboratory phenotypes, and heavy drinking in late adolescence. Addiction Biology, 22, 1343-1354.

Hendershot, C.S., & Nona, C.N. (2017). A review of developmental considerations in human laboratory alcohol research. Current Addiction Reports, 4, 364-378.

Dermody, S.S., & Hendershot, C.S. (2017). A critical review of the effects of nicotine and alcohol co-administration in human laboratory studies. Alcoholism: Clinical and Experimental Research, 41(3): 473-486.

Hendershot, C.S., Claus, E.D., & Ramchandani, V.A. (2016). Associations of OPRM1 A118G and alcohol sensitivity with intravenous alcohol self-administration in young adults. Addiction Biology, 21(1), 125-135.

Hendershot, C.S., Wardell, J.D., Strang, N.M., Markovich, M.S.D., Claus, E.D., & Ramchandani, V.A. (2015). Application of an alcohol clamp paradigm to examine inhibitory control, subjective responses and acute tolerance in late adolescence. Experimental and Clinical Psychopharmacology, 23, 147-158.

Strang, N.M., Claus, E.D., Ramchandani, V.A., Graff-Guerrero, A., Boileau, I., & Hendershot, C.S. (2015). Dose-dependent effects of intravenous alcohol administration on cerebral blood flow in young adults. Psychopharmacology, 232(4): 733-744.

Hendershot, C.S. (2014). Pharmacogenetic approaches in the treatment of alcohol use disorders: Addressing clinical utility and implementation thresholds. Addiction Science and Clinical Practice, 9:20.

Hendershot, C.S., Otto, J.M., Collins, S.E., Liang, T., & Wall, T.L. (2010). Evaluation of a brief web-based genetic feedback intervention for reducing alcohol-related health risks associated with ALDH2. Annals of Behavioral Medicine, 40(1), 77-88.