Faculty: Benjamin I. Goldstein, MD, PhD, FRCP(C)
Departments of Psychiatry, Pharmacology & Toxicology, University of Toronto
Director, Centre for Youth Bipolar Disorder
Director of Research, Department of Psychiatry
Scientist, Sunnybrook Research Institute, Sunnybrook Health Sciences Center
General Research Areas: Neuropharmacology/Psychopharmacology; Cardiovascular Pharmacology; Toxicology
Dr. Goldstein’s research focuses on bipolar disorder. Adolescents with bipolar disorder, or those at high clinical and/or familial risk of bipolar disorder, comprise the primary subject group. The primary areas of inquiry are the overlap between bipolar disorder and cardiovascular disease (CVD), and the identification of biomarkers for use in the assessment, monitoring, and treatment of these patients.
- To identify biomarkers that can inform clinical decisions in the area of adolescent bipolar disorder
- To gain knowledge regarding biological factors underlying the association between bipolar disorder and cardiovascular disease
- To identify novel objective treatment targets in bipolar disorder using neuroimaging (MRI) and neurocognitive phenotypes
Newton D, Naiberg M, Andreazza A, Scola G, Dickstein D, Collins J, Goldstein BI. Association of lipid peroxidation and brain-derived neurotrophic factor with executive function in adolescent bipolar disorder. Psychopharmacology. 2017. In Press.
Hatch JK, Scola G, Olowoyeye O, Collins JE, Andreazza AC, Moody A, Levitt AJ, Strauss BH, Lanctot KL, Goldstein BI. Inflammatory markers and brain-derived neurotrophic factor as potential bridges linking bipolar disorder and cardiovascular risk among adolescents. Journal of Clinical Psychiatry. 2017. In Press.
MacIntosh BJ, Shirzadi Z, Scavone A, Metcalfe AWS, Islam AH, Korczak D, Goldstein BI. Increased cerebral blood flow among adolescents with bipolar disorder at rest is reduced following acute aerobic exercise. Journal of Affective Disorders. 2017 Jan;208:205-213.
Naiberg MR, Newton DF, Collins JE, Bowie CR, Goldstein BI. Impulsivity is associated with blood pressure and waist circumference among adolescents with bipolar disorder. Journal of Psychiatric Research. 2016 Dec;83:230-239.
Naiberg MR, Newton DF, Collins JE, Dickstein DP, Bowie CR, Goldstein BI. Elevated triglycerides are associated with decreased executive function among adolescents with bipolar disorder. Acta Psychiatrica Scandinavica. 2016 Sep;134(3):241-8.
Metcalfe AWS, MacIntosh BJ, Scavone A, Ou X, Korczak D, Goldstein BI. Effects of acute aerobic exercise on neural correlates of attention and inhibition in adolescents with bipolar disorder. Translational Psychiatry. 2016 May;6:e814.
Goldstein BI, Carnethon MR, Matthews KA, McIntyre RS, Miller GE, Raghuveer G, Stoney CM, Wasiak H, McCrindle BW; American Heart Association Atherosclerosis, Hypertension and Obesity in Youth Committee of the Council on Cardiovascular Disease in the Young. Major depressive disorder and bipolar disorder predispose youth to accelerated atherosclerosis and early cardiovascular disease: a scientific statement from the American Heart Association. Circulation. 2015 Sep 8;132(10):965–86.
Hatch J, Andreazza A, Olowoyeye O, Rezin GT, Moody A, Goldstein BI. Cardiovascular and psychiatric characteristics associated with oxidative stress markers among adolescents with bipolar disorder. J Psychosom Res. 2015 Sep ;79(3):222–7.
Goldstein BI, Schaffer A, Wang S, Blanco C. Excessive and premature new-onset cardiovascular disease among adults with bipolar disorder in the US NESARC cohort. J Clin Psychiatry. 2015 Feb;76(2):163–9.
Goldstein BI, Young LT. Toward clinically applicable biomarkers in bipolar disorder: focus on BDNF, inflammatory markers, and endothelial function. Curr Psychiatry Rep.2013 Dec;15(12):425.
Goldstein BI, Collinger KA, Lotrich F, Marsland AL, Gill MK, Axelson DA, Birmaher B. Preliminary findings regarding proinflammatory markers and brain-derived neurotrophic factor among adolescents with bipolar spectrum disorders. J Child and Adolescent Psychopharmacology, 2011 Oct; 21(5):479-484.
Goldstein BI, Kemp DE, Soczynska JK, McIntyre RS. Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: a systematic review of the literature. J Clin Psychiatry, 2009 Aug; 70(8):1078-1090.
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