Faculty: Anh Dzung Le, PhD
Head, Neurobiology of Alcohol Section, Neuroscience Department
Center for Addiction and Mental Health
General Research Area: Alcoholism & Drug Addiction
Neurochemical Mechanisms of Alcohol Dependence
The focus of our studies is to understand the neurochemical mechanisms underlying the effects of stress on relapse to alcohol. Presently, the role of Corticotropin Releasing Factor(CRF) and serotonin on reinstatement of alcohol seeking are being studied. Another major line of work is the interaction between alcohol and nicotine. We have found that nicotine can increase alcohol consumption as well as promote relaps eto alcohol in our animal models. We are currently investigated the influence of exposure to nicotine during adolescent period on subsequent development of abuse to nicotine and alcohol.
Shram M, Li Z, Funk D and Lê AD. Nicotine Self-Administration, Extinction Responding and Reinstatement in Adolescent and Adult Male Rats: Evidence Against a Biological Vulnerability to Nicotine Addiction during Adolescence. Neuropsychopharmacology. 2009; 33:739-748
Shram MJ, Siu R, Li Z, Tyndale RF and Lê AD. Interaction between age and the aversive effect of nicotine withdrawal under mecamylamine-precipitated and spontaneous conditions in Male Wistar rats. Psychopharmacology. 2008; 198:181-190.
Marinelli PW, Funk D, Juzytsch W, Li Z, Lê AD. Effects of opioid receptor blockade on the renewal of alcohol seeking induced by context: relationship to c-fos mRNA expression. Eur J Neurosci. 2007; 26(10):2815-23.
Marinelli PW, Funk D, Juzytsch W, Harding S, Rice KC, Shaham Y, Lê AD. The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats. Psychopharmacology (Berl). 2007 Dec;195(3):345-55. Epub 2007 Aug 20.
Shram MJ, Funk D, Li Z, Lê AD. Nicotine Self-Administration, Extinction Responding and Reinstatement in Adolescent and Adult Male Rats: Evidence Against a Biological Vulnerability to Nicotine Addiction during Adolescence. Neuropsychopharmacology. 2008 Mar; 33(4):739-48. Epub 2007 May 16.
Lê A.D., Li, Z, Funk , D. Shram , M, Li, T.K and Y. Shaham.) Increased vulnerability to nicotine self administration and relapse in alcohol-naive offspring of rats selectively bred for high alcohol intake. J Neurosci. 2006; 26(6):1872-1879.
Funk D, Marinelli PW, Lê AD. Biological processes underlying co-use of alcohol and nicotine: neuronal mechanisms, cross-tolerance, and genetic factors. Alcohol Res Health. 2006; 29(3):186-92; Review.
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