Pharmacology and Toxicology

Dr. Krishna Singh

Dr. Krishna Singh, PhD.Dr. Krishna Singh, PhD. Dr. Krishna Kumar Singh
Assistant Professor, University of Toronto
Professor, Western University
Tel: 519.661.2111 ext. 85683


Dr. Krishna Singh obtained his PhD in Molecular Medicine in 2006 from Hannover Medical School (MHH), Germany, where he was one of 20 international students selected for the “International MD/PhD Program in Molecular Medicine”. His research interest centers on understanding the cellular mechanisms that contribute to cardiovascular diseases, with the aim of identifying molecular targets for therapeutic advancement. His inventive research has been published in many top-tier journals; e.g. Nature Communication, The Journal of Biological Chemistry, Human Mutation, Oncotarget, Aging Cell, etc. He has received various international and national awards for his research, including the prestigious Vivien Thomas Young Investigator Award from the American Heart Association, Expert Opinions Clinical Impacts Award, Canada and Heart & Stroke Foundation of Canada/ Pfizer Research Fellow Award.


Research interests: Cardiovascular diseases, Fibrosis, Marfan syndrome, Atherosclerosis, Autophagy, DNA – damage repair & Endothelial-to-mesenchymal Transition.


Recent Publications:

  1. Mantella, LE, Singh, KK, Sandhu, P, Kantores, C, Ramadan, A, Khyzha, N et al.. Fingerprint of long non-coding RNA regulated by cyclic mechanical stretch in human aortic smooth muscle cells: implications for hypertension. Mol. Cell. Biochem. 2017; :. doi: 10.1007/s11010-017-3065-2. PubMed PMID:28526936 .
  2. Yau, JW, Singh, KK, Hou, Y, Lei, X, Ramadan, A, Quan, A et al.. Endothelial-specific deletion of autophagy-related 7 (ATG7) attenuates arterial thrombosis in mice. J. Thorac. Cardiovasc. Surg. 2017; :. doi: 10.1016/j.jtcvs.2017.02.058. PubMed PMID:28400112 .
  3. Shi, X, Verma, S, Yun, J, Brand-Arzamendi, K, Singh, KK, Liu, X et al.. Effect of empagliflozin on cardiac biomarkers in a zebrafish model of heart failure: clues to the EMPA-REG OUTCOME trial?. Mol. Cell. Biochem. 2017; :. doi: 10.1007/s11010-017-3018-9. PubMed PMID:28391552 .
  4. Singh, KK, Matkar, PN, Pan, Y, Quan, A, Gupta, V, Teoh, H et al.. Endothelial long non-coding RNAs regulated by oxidized LDL. Mol. Cell. Biochem. 2017;431 (1-2):139-149. doi: 10.1007/s11010-017-2984-2. PubMed PMID:28316063 .
  5. Quan, A, Pan, Y, Singh, KK, Polemidiotis, J, Teoh, H, Leong-Poi, H et al.. Cardiovascular inflammation is reduced with methotrexate in diabetes. Mol. Cell. Biochem. 2017; :. doi: 10.1007/s11010-017-3006-0. PubMed PMID:28303409 .
  6. Kwan, V, Meka, DP, White, SH, Hung, CL, Holzapfel, NT, Walker, S et al.. DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants. Cell Rep. 2016;17 (7):1892-1904. doi: 10.1016/j.celrep.2016.10.047. PubMed PMID:27829159 .
  7. Singh, KK, Matkar, PN, Muhammad, S, Quan, A, Gupta, V, Teoh, H et al.. Investigation of novel LPS-induced differentially expressed long non-coding RNAs in endothelial cells. Mol. Cell. Biochem. 2016;421 (1-2):157-68. doi: 10.1007/s11010-016-2797-8. PubMed PMID:27565812 .
  8. Matkar, PN, Singh, KK, Rudenko, D, Kim, YJ, Kuliszewski, MA, Prud'homme, GJ et al.. Novel regulatory role of neuropilin-1 in endothelial-to-mesenchymal transition and fibrosis in pancreatic ductal adenocarcinoma. Oncotarget. 2016;7 (43):69489-69506. doi: 10.18632/oncotarget.11060. PubMed PMID:27542226 PubMed Central PMC5342493.
  9. Singh, KK, Mantella, LE, Pan, Y, Quan, A, Sabongui, S, Sandhu, P et al.. A global profile of glucose-sensitive endothelial-expressed long non-coding RNAs. Can. J. Physiol. Pharmacol. 2016;94 (9):1007-14. doi: 10.1139/cjpp-2015-0585. PubMed PMID:27434139.
  10. Singh, KK, Matkar, PN, Quan, A, Mantella, LE, Teoh, H, Al-Omran, M et al.. Investigation of TGFβ1-Induced Long Noncoding RNAs in Endothelial Cells. Int J Vasc Med. 2016;2016 :2459687. doi: 10.1155/2016/2459687. PubMed PMID:27144026 PubMed Central PMC4842052.

Publication Link:,+Toronto+OR+Singh+KK,+Schmidtke